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Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WLN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC011 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC010 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome analysis in Human Airway Epithelial (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants in a longitudinal study...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson MERS-CoV Experiment MCL003 The purpose of this experiment was to evaluate the human host response to wild-type infectious clone of Middle Eastern Respiratory Syndrome coronavirus (icMERS-CoV) infection and mockulum. Sample data was obtained...