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Omics-LHV, West Nile Experiment WDC010 The purpose of this West Nile experiment was to obtain samples for omics analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Overall Design: Mouse (C57Bl/6J) primary amyeloid dendritic...

Omics-LHV, West Nile Experiment WCN004 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cerebral cortex neurons in response to wild-type West Nile Virus (WNV; WNV-NY99 382) and mutant WNV-E218A (WNV-NY99 382) viral infection. Overall Design: Mouse cortical...

Omics-LHV, West Nile Experiment WCN003 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse cortical neuron collections infected with wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant West Nile virus (WNVE218A). This data set comprises two...

Omics-LHV, West Nile Experiment WCN002 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse cortical neuron collections infected with wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant West Nile virus (WNVE218A). This data set comprises two...

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...

Omics-LHV, West Nile Experiment WCD003 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse dendritic cell response to wild-type West Nile virus (WNV). Overall Design: Mouse dendritic cells (2 x 10^5) were treated with wild-type WNV and collected in parallel...

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...

Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...

The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...

Reusable Digital Data Lifecycle Downloads for Omics-Lethal Human Virus Systems Biology The Omics-LHV Systems Virology project was one of four projects, funded by the NIAID Systems Biology for Infectious Diseases Research Program (funded from 2008-2013), was established in developing and validating...

Integrative Omics

Datasets
11

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for...

Integrative Omics

Datasets
11

Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SHAE004 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome analysis in Human Airway Epithelial (HAE) cells infected with SARS-CoV, SARS deltaORF6, SARS BatSRBD mutants in a longitudinal study...

Omics-LHV, MERS Experiment MCL003 The purpose of this MERS experiment was to obtain samples for omics analysis of human Calu-3 cell response to treated with wild-type icMERS-CoV and mockulum. For proteomics, lipidomics, and metabolomics data from the Calu-3 cells infected with MERS-CoV, the...