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Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...

Ebola Experiment EH001 Multi-platform omics analyses of peripheral blood mononuclear cells and plasma derived from human patients infected with Ebola ΔVP30 virus from Sierra Leone. Patients with fatal EVD succumbed to the infection before additional samples could be collected. In total, 29 samples...

Omics-LHV, West Nile Experiment WLN002 The purpose of this West Nile experiment was to obtain serum samples for transcriptome analysis in mouse popliteal draining lymph nodes (DLN) infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall...

Omics-LHV, West Nile Experiment WCT001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cortex tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with WNV...

Omics-LHV, West Nile Experiment WCB001 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cerebellum tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice were inoculated with...

Omics-LHV, Influenza Experiment IM103 The purpose of this Influenza experiment was to obtain samples for mRNA, miRNA, proteomics, lipidomics, and metabolomics analysis in mouse lung infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'). Overall Design: Groups of 22-week-old C57BL/6 mice were...

Influenza A Experiment IM102 The purpose of this Influenza experiment was to obtain samples for mRNA, miRNA, proteomics, lipidomics, and metabolomics analysis in mouse lung infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Overall Design: Groups...

Omics-LHV Influenza Experiment IM101 The purpose of this Influenza experiment was to obtain samples for mRNA and miRNA analysis in mouse lung infected with WT A/Vietnam/1203/2004 (H5N1; 'VN1203'), VN12013-PB2-627E, VN1203-NS1trunc124, and WT A/California/04/2009 (H1N1; 'CA04'). Overall Design...

Influenza A Experiment ICL104 The purpose of this experiment was to evaluate the host response to Influenza A pandemic wild-type H1N1 (A/California/04/2009), natural isolate virus. Sample data was obtained for human Calu-3 cells infected with wild-type H1N1 virus (A/California/04/2009) for mRNA...

Influenza A Experiment ICL103 The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H5N1) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT Influenza A/Vietnam/1203/2004 (H5N1, VN1203) and...

Influenza A Experiment ICL102 The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H7N9) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT H7N9 (A/Anhui/1/2013; AH1) and NS1-L103F/I106M for...

Ebola Experiment EU937001 The purpose is to obtain samples for transcriptome analysis in in human U937 cells infected with Zaire Ebola virus wild-type in the ΔVP30 background and Δmucin virus. Overall Design: Human U937 cells (monocyte-like) expressing the Ebola VP30 protein were infected with Zaire...

Ebola Experiment EIHH002 Processed Omics Data Unavailable This experiment evaluated Immortalized Human Hepatocyte (IHH) cell line host response to response to genetically-reconstructed Zaire Ebola virus infection. Related Experimental Data BioProject: PRJNA287217, PRJNA287216 GEO Accession: GSE69942...

Ebola Experiment EIHH001 Processed Omics Data Unavailable This experiment evaluated Immortalized Human Hepatocyte (IHH) cell line host response to wild-type Ebola viruses Zaire Ebola (ZEBOV '76) and Reston Ebola (REBOV '08) viral infection. Related Primary Data profiling by array BioProject...