Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
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Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
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The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
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Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
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Dataset
Viral genome assembly annotations from terabase metagenomes (TmG.1.0) from uncultivated soil collections from the IAREC field sites in Washington (IAREC), Kansas (KBPS), and Iowa (COBS), USA. Uncultivated virus Genomes (identified from soil metagenome datasets) Data DOI Package.
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Code pertaining to the Soil Microbiome SFA Project publication data visualizations 'DNA viral diversity, abundance and functional potential vary across grassland soils with a range of historical moisture regimes' for processing publication data downloads.
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Person
Data Science & Biostatistics
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Person
Dr. Paul Piehowski is the Proteomics team leader for PNNL’s Environmental and Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. Piehowski is an analytical chemist whose research is focused on the application of mass spectrometry to biological...
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Publication
Exhaled breath condensate proteomics represent a low-cost, non-invasive alternative for examining upper respiratory health. EBC has previously been used for the discovery and validation of detected exhaled volatiles and non-volatile biomarkers of disease related to upper respiratory system distress...
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Dr. Gao obtained her Ph.D degree in Chemistry from institute of chemistry, Chinese Academy of Science. His Ph.D research focused on multiscale modeling of morphology and properties of polymeric materials, polymer processing and unveiling the process–properties relationships. (atomic to coarse...
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Viral communities detected from three large grassland soil metagenomes with historically different precipitation moisture regimes.
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Dataset
Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from KPBS field site in Manhattan, KS. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.
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Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from COBS field site in Boone County, IA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.
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Dataset
Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from IAREC field site in Prosser, WA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.
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Viral communities detected from three large grassland soil metagenomes with historically different precipitation moisture regimes.