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Systems Virology Lethal Human Virus, SARS-CoV Experiment SM012 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57Bl/6 mice infected with SARS MA15 or SARS deltaORF6 mutant viruses. Overall Design: Twenty-week-old C57BL/6 mice...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SM003 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57BlL/6 mice lung infected with dicSARS CoV, SARS MA15 wild type and SARS BatSRBD mutant virus. Overall Design...

Omics Lethal Human Virus, SARS-CoV Experiment SM001 New uploads pending The purpose of this experiment was to evaluate the human host response to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) wild-type virus. Sample data was obtained for 20 week-old C57BL/6J mouse lung tissue infected...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WSE001 The purpose of this experiment was to evaluate the host response to wild-type West Nile (WNV-NY99 382) virus infection. Sample data was obtained from mouse (C57BL6/JAX) serum from mock-treated "Koolaid" and...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WLN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC011 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC010 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...