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Systems Virology Lethal Human Virus, SARS-CoV Experiment SM012 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57Bl/6 mice infected with SARS MA15 or SARS deltaORF6 mutant viruses. Overall Design: Twenty-week-old C57BL/6 mice...

Systems Virology Lethal Human Virus, SARS-CoV Experiment SM003 New uploads pending The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57BlL/6 mice lung infected with dicSARS CoV, SARS MA15 wild type and SARS BatSRBD mutant virus. Overall Design...

Omics-LHV, West Nile Experiment WLN003 The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse popliteal draining lymph nodes (DLN) infected with wild-type West Nile virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt). Overall Design: Mice...

Integrative Omics

Omics-LHV, West Nile Experiment WGCN003 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse granule cell neurons infected with wild type West Nile virus (WNV-NY99 clone 382, WNVWT) and mutant virus (WNVE218A). Overall Design: Granule cell neurons from...

Integrative Omics

Omics-LHV, West Nile Experiment WGCN002 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse granule cell neurons infected with wild type West Nile virus (WNV-NY99 clone 382, WNVWT) and mutant virus (WNVE218A). Overall Design: Granule cell neurons from...

Integrative Omics

Omics-LHV, West Nile Experiment WDC011 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Overall Design: Mouse (C57Bl/6J) primary amyeloid...

Integrative Omics

Omics-LHV, West Nile Experiment WDC010 The purpose of this West Nile experiment was to obtain samples for omics analysis in primary mouse myeloid dendritic cells infected with wild type West Nile virus (WNVMT) and mutant virus (WNVE218A). Overall Design: Mouse (C57Bl/6J) primary amyeloid dendritic...

Omics-LHV, West Nile Experiment WCN003 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse cortical neuron collections infected with wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant West Nile virus (WNVE218A). This data set comprises two...

Omics-LHV, West Nile Experiment WCN002 The purpose of this West Nile experiment was to obtain samples for transcriptome analysis in mouse cortical neuron collections infected with wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant West Nile virus (WNVE218A). This data set comprises two...

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...

Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...

The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...

Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...