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Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WSE001 The purpose of this experiment was to evaluate the host response to wild-type West Nile (WNV-NY99 382) virus infection. Sample data was obtained from mouse (C57BL6/JAX) serum from mock-treated "Koolaid" and...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WLN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt) virus infection. Sample data...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WGCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC011 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WDC010 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNVMT) and mutant (WNVE218A) virus infection. Sample data was obtained from primary mouse myeloid dendritic cells...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN003 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Integrative Omics

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson West Nile Virus Experiment WCN002 The purpose of this experiment was to evaluate the host response to wild-type West Nile virus (WNV-NY99 382) and mutant (WNV-E218A) virus infection. Sample data was obtained from mouse mouse cortical neurons...

Integrative Omics

Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...

The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...

Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...

The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...

Reusable Digital Data Lifecycle Downloads for Omics-Lethal Human Virus Systems Biology The Omics-LHV Systems Virology project was one of four projects, funded by the NIAID Systems Biology for Infectious Diseases Research Program (funded from 2008-2013), was established in developing and validating...

Integrative Omics

Datasets
11

The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for...

Integrative Omics

Datasets
11