Project - Modelling Omics-Lethal Human Viruses, SARS

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection

The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for Infectious Diseases Research Programs develop and validate predictive models of infectious disease initiation, progression, and outcomes. These models are derived from the study of the architecture and dynamics of systems-wide host/pathogen molecular interaction networks during infection, using integrated datasets generated from a combination of "omics" technologies. The research findings will provide a deeper understanding of the overall complexity of the biological, biochemical, and biophysical molecular processes within microbial organisms as well as their interaction with the host.

Dataset downloads contain one or more statistically processed data files related to a transcriptomic, proteomic, metabolomic, and/or lipidomic dataset collection associated with a Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) experimental study. 

Viral Infection Experimental Factors

Virus Subtypes

1. SARS-CoV MA15 (mouse-adapted)
2. icSARS CoV Urbani wild-type, icSARS dORF6 mutant, icSARS-deltaNSP16 mutant, icSARS ExoNI mutant
3. icSARS Bat SRBD (bat virus expressing spike receptor binding domain from WT Urbani)

Host Organisms

• Homo sapiens
• Mus Musculus

Acknowledgements

The datasets described here were funded in whole or in part by the National Institute of Allergy and Infectious Diseases National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272200800060C. Omics data generated by the Systems Virology Proteomics, Metabolomics, and Lipidomics Core were performed at Pacific Northwest National Laboratory (PNNL) in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office of Biological and Environmental Research located in Richland, WA. PNNL is operated by the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Recommended Citation

Anderson LN, McDermott J, Waters K, Sims A, Baric R. (2021). Omics Lethal Human Viruses Project, Modeling Host Responses to Severe Acute Respiratory Syndrome (SARS) Infection Post-Processed Data Package DOIs. PNNL DataHub. https://data.pnnl.gov/group/nodes/project/13308. DOI: https://doi.org/10.25584/LHVSARS/1813912