Citation: Gosline, S.J.C., Kim, D.N., Pande, P. et al. The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. Sci Data 10 , 151 (2023). https://doi.org/10.1038/s41597-023-02021-5 Funding Acknowledgments The research reported herein was...
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The srpAnalytics modeling pipeline for processing new data for the OSU-PNNL Superfund Research Program Analytics Portal located at https://github.com/sgosline/srpAnalytics Data License MIT License Copyright (c) 2020 Sara JC Gosline . Permission is hereby granted, free of charge, to any person...
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OSU-PNNL Superfund Research Program Center is part of the Superfund Research Program (SRP) at Oregon State University, directed by Dr. Robyn Tanguay, bringing together a multidisciplinary team of experts with extensive experience in polycyclic aromatic hydrocarbons (PAHs) research. Using state-of...
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https://www.nih.gov/about-nih/what-we-do/mission-goals NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The goals of the agency are: to foster...
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Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
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The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
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Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
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The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
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Publication
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
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Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
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The Community Land Model (CLM) is an effective tool to simulate the biophysical and biogeochemical processes and their interactions with the atmosphere. Although CLM Version 5 (CLM5) constitutes various updates in these processes, its performance in simulating energy, water and carbon cycles over...
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Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection Background The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host...
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