Systems Virology Lethal Human Virus, SARS-CoV Experiment SM003

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Systems Virology Lethal Human Virus, SARS-CoV Experiment SM003

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The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57BlL/6 mice lung infected with dicSARS CoV, SARS MA15 wild type and SARS BatSRBD mutant virus.

Overall Design: Twenty-week-old C57BL/6 mice were infected icSARS CoV, Wild Type SARS MA15 or SARS BatSRBD mutant viruses at 10^4 or 10^5 PFU (mock-infected with PBS alone). Lungs were harvested and total RNA was isolated and subjected to microarray analysis (experimental design was for 3-5 mice/time point/dose and 3 time-matched mocks). Time points used were: 1, 2, 4 and 7 days post-infection.


Processed Omics Data (available at download button):

Dataset downloads contain one or more statistically processed data file related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated with the SARS experimental study.





Related Experimental Data

BioProject:  PRJNA215773

GEO Dataset: GSE50000

Peptide Atlas: PASS00433 (PNNL Systems Virology Contract Data)

Host Factor Experiment(s): SM003-R (ViPR, NIAID Systems Biology)

DOI: 10.1073/pnas.080811610510.1371/journal.ppat.003000510.1128/mBio.00638-1510.1128/mBio.01753-1810.3389/fcell.2019.00200

Publications (2)
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...