Systems Virology Lethal Human Virus, SARS-CoV Experiment SM012

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Systems Virology Lethal Human Virus, SARS-CoV Experiment SM012

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The purpose of this SARS experiment was to obtain samples for transcriptome and proteome analysis in C57Bl/6 mice infected with SARS MA15 or SARS deltaORF6 mutant viruses.

Overall Design: Twenty-week-old C57BL/6 mice were infected with wild type SARS MA15 or SARS deltaORF6 mutant viruses at 10^5 PFU. Infected samples included time-matched mock collections in parallel. Lung samples were collected for virus load for 3 mice/time point/dose. Time points used were: 1, 2, 4 and 7 days post-infection.

Processed Omics Data (available at download button):

Dataset downloads contain one or more statistically processed data file related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated with the SARS experimental study.





Related Experimental Data

BioProject:  PRJNA213462

GEO Dataset: GSE49262

Host Factor Experiment(s): SM012-R (ViPR, NIAID Systems Biology)

DOI: 10.3389/fcell.2019.00200

Projects (2)
Omics-Lethal Human Viruses, SARS
NIAID Systems Biology for Infectious Diseases Research Program Processed Data
Publications (3)
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
A comprehensive collection of systems biology data characterizing the host response to viral infection
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...