Dr. Smith's research interests span the development of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research. This has included creating and applying new ultra-sensitive technologies to quantitatively probe the entire arrays of proteins (i.e. proteomes) expressed by cells, tissues, and organisms. In the last decade, these efforts have broadened to include development and application of highly sensitive, high-throughput technologies for measuring the "pan-ome, (the array of biomolecule measurements that include the proteome, metabolome, lipidome, and glycome, to augment biological research. To enable much more effective pan-omics applications, he has recently lead the development of novel Structures for Lossless Ion Manipulations (SLIM) and their use for very-high-throughput sample processing, reactions, separations, and other manipulations of ions in the gas phase, and particularly in conjunction with mass spectrometry.
Dr. Smith also is Director of Proteome Research at PNNL, Director of the NIH Research Resource for Integrative Biology, an adjunct faculty member in the chemistry departments at Washington State University and the University of Utah, and an affiliate faculty member in the Department of Chemistry at the University of Idaho and the Department of Molecular Microbiology & Immunology at Oregon Health & Science University. Dr. Smith completed his Ph.D. work in Physical Chemistry at the University of Utah.
Dr. Smith is the author/co-author of more than 1100 peer-reviewed journal articles and is the recipient of 70 patents and 12 R&D 100 Awards.
- Development and application of advanced analytical methods and instrumentation, with particular emphasis on high-resolution separations and mass spectrometry, and their applications in biological and biomedical research
- Development and application of new ultra-sensitive methods for quantitatively probing the entire array of proteins expressed by a cell, tissue or organism, i.e., their "proteomes"
- Increasing the throughput and sensitivity of proteomics, metabolomics, and other pan-omics measurements to augment systems biology research
Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection Background The National Institute of Allergy and Infectious Diseases ( NIAID ) "Modeling Host...