Publication - Journal Article Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model

Blood, vol. 121, iss. 18, pp. 3759-3767, 2013

Johnnie J. Orozco, Tom Bäck, Aimee Kenoyer, Ethan R. Balkin, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Shani L. Frayo, Mark D. Hylarides, Damian J. Green, Ajay K. Gopal, Oliver W. Press, John M. Pagel

Key Points Astatination of anti-CD45 antibody via a closo-decaborate compound yields a stable conjugate that targets radiation to hematologic organs. 211At-anti-CD45 radioimmunotherapy combined with bone marrow transplantation prolongs survival in a disseminated murine leukemia model.