Publication - Journal Article Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model

Blood, vol. 125, iss. 13, pp. 2111-2119, 2015

Damian J. Green, Mazyar Shadman, Jon C. Jones, Shani L. Frayo, Aimee L. Kenoyer, Mark D. Hylarides, Donald K. Hamlin, D. Scott Wilbur, Ethan R. Balkan, Yukang Lin, Brian W. Miller, Sofia H. L. Frost, Ajay K. Gopal, Johnnie J. Orozco, Theodore A. Gooley, Kelly L. Laird, Brian G. Till, Tom Bäck, Brenda M. Sandmaier, John M. Pagel, Oliver W. Press

Key Points α-Emitting radionuclides have the potential to overcome treatment-resistant lymphoma cell clones that evade other forms of therapy. 211At-labeled anti-CD20 monoclonal antibody eradicates lymphoma in a mouse minimal residual disease model.