Journal Article
mSystems, vol. 1, iss. 4, 2016
Authors
Ryan L. Sontag, Ernesto S. Nakayasu, Roslyn N. Brown, George S. Niemann, Michael A. Sydor, Octavio Sanchez, Charles Ansong, Shao-Yeh Lu, Hyungwon Choi, Dylan Valleau, Karl K. Weitz, Alexei Savchenko, Eric D. Cambronne, Joshua N. Adkins, Margaret J. McFall-Ngai
Abstract
During infection, pathogenic bacteria face an adverse environment of factors driven by both cellular and humoral defense mechanisms. To help evade the immune response and ultimately proliferate inside the host, many bacteria evolved specialized secretion systems to deliver effector proteins directly into host cells. Translocated effector proteins function to subvert host defense mechanisms. Numerous pathogenic bacteria use a specialized secretion system called type III secretion to deliver effectors into the host cell cytosol. Here, we identified 75 new host targets of
Salmonella
and
Citrobacter
effectors, which will help elucidate their mechanisms of action.
