Journal Article
mSphere, vol. 3, iss. 3, 2018
Authors
Kathleen Nudel, Ryan McClure, Matthew Moreau, Emma Briars, A. Jeanine Abrams, Brian Tjaden, Xiao-Hong Su, David Trees, Peter A. Rice, Paola Massari, Caroline A. Genco, Sarah E. F. D'Orazio
Abstract
Recent emergence of antimicrobial resistance of
Neisseria gonorrhoeae
worldwide has resulted in limited therapeutic choices for treatment of infections caused by this organism. We performed global transcriptomic analysis of
N. gonorrhoeae
in subjects with gonorrhea who attended a Nanjing, China, sexually transmitted infection (STI) clinic, where antimicrobial resistance of
N. gonorrhoeae
is high and increasing. We found that
N. gonorrhoeae
transcriptional responses to infection differed in genital specimens taken from men and women, particularly antibiotic resistance gene expression, which was increased in men. These sex-specific findings may provide a new approach to guide therapeutic interventions and preventive measures that are also sex specific while providing additional insight to address antimicrobial resistance of
N. gonorrhoeae
.
