Journal Article
Proceedings of the National Academy of Sciences, vol. 115, iss. 5, 2018
Authors
Vineet D. Menachery, Alexandra Schäfer, Kristin E. Burnum-Johnson, Hugh D. Mitchell, Amie J. Eisfeld, Kevin B. Walters, Carrie D. Nicora, Samuel O. Purvine, Cameron P. Casey, Matthew E. Monroe, Karl K. Weitz, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Lisa E. Gralinski, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Amy C. Sims, Yoshihiro Kawaoka, Ralph S. Baric
Abstract
Significance
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.
