Journal Article
mSphere, vol. 2, iss. 1, 2017
Authors
Kyle R. Pomraning, Erin L. Bredeweg, Scott E. Baker, Aaron P. Mitchell
Abstract
Nitrogen source is commonly used to control lipid production in industrial fungi. Here we identified regulators of nitrogen catabolite repression in the oleaginous yeast
Y. lipolytica
to determine how the nitrogen source regulates lipid metabolism. We show that disruption of both activators and repressors of nitrogen catabolite repression leads to increased lipid accumulation via activation of carbon catabolite repression through an as yet uncharacterized method.
