Publication - Journal Article Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

https://doi.org/10.1073/pnas.1815356116
Journal Article
Proceedings of the National Academy of Sciences, vol. 116, iss. 9, pp. 3919-3928, 2019
Authors
J. E. Kyle, K. E. Burnum-Johnson, J. P. Wendler, A. J. Eisfeld, Peter J. Halfmann, Tokiko Watanabe, Foday Sahr, R. D. Smith, Y. Kawaoka, K. M. Waters, T. O. Metz
Abstract
Significance Outbreaks of Ebola virus disease (EVD) continue to emerge with severe and often deadly outcomes and global consequences. Novel strategies for examining host response differences that distinguish EVD survivors and fatalities can only deepen our understanding of the disease and expand diagnostic and treatment options. Lipids are major molecular constituents in human plasma with important structural, transport, energy, and signaling functions. Here we provide a comprehensive examination of the EVD lipidome. Using liquid chromatography tandem mass spectrometry, we profiled the human plasma lipidome of patients that survived and succumbed to EVD during the 2014 outbreak in Sierra Leone. The results highlight the profound impact of EVD on the host lipidome, leading to possible therapies for improving EVD survival.
Projects (1)
Project
NIAID Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Last updated on 2023-05-05T16:36:07+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection The National Institute of Allergy and Infectious Diseases ( NIAID ) "Modeling Host Responses...

Biology
Human Health
Integrative Omics

  1. Datasets

    45
English