Plasma lipidome reveals critical illness and recovery from human Ebola virus disease

Journal Article
Proceedings of the National Academy of Sciences, vol. 116, iss. 9, pp. 3919-3928, 2019
J. E. Kyle, K. E. Burnum-Johnson, J. P. Wendler, A. J. Eisfeld, Peter J. Halfmann, Tokiko Watanabe, Foday Sahr, R. D. Smith, Y. Kawaoka, K. M. Waters, T. O. Metz
Significance Outbreaks of Ebola virus disease (EVD) continue to emerge with severe and often deadly outcomes and global consequences. Novel strategies for examining host response differences that distinguish EVD survivors and fatalities can only deepen our understanding of the disease and expand diagnostic and treatment options. Lipids are major molecular constituents in human plasma with important structural, transport, energy, and signaling functions. Here we provide a comprehensive examination of the EVD lipidome. Using liquid chromatography tandem mass spectrometry, we profiled the human plasma lipidome of patients that survived and succumbed to EVD during the 2014 outbreak in Sierra Leone. The results highlight the profound impact of EVD on the host lipidome, leading to possible therapies for improving EVD survival.
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