Publication - Journal Article A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets

https://doi.org/10.1128/mbio.02972-21
Journal Article
mBio, vol. 12, iss. 6, 2021
Authors
Daniel Zamith-Miranda, Heino M. Heyman, Meagan C. Burnet, Sneha P. Couvillion, Xueyun Zheng, Nathalie Munoz, William C. Nelson, Jennifer E. Kyle, Erika M. Zink, Karl K. Weitz, Kent J. Bloodsworth, Geremy Clair, Jeremy D. Zucker, Jeremy R. Teuton, Samuel H. Payne, Young-Mo Kim, Morayma Reyes Gil, Erin S. Baker, Erin L. Bredeweg, Joshua D. Nosanchuk, Ernesto S. Nakayasu, James W. Kronstad
Abstract
It is estimated that 150 people die per hour due to the insufficient therapeutic treatments to combat fungal infections. A major hurdle to developing antifungal therapies is the scarce knowledge on the fungal metabolic pathways and mechanisms of virulence.
English