The Legionella Effector SdjA Is a Bifunctional Enzyme That Distinctly Regulates Phosphoribosyl Ubiquitination

Journal Article
mBio, vol. 12, iss. 5, 2021
Lei Song, Yongchao Xie, Chuang Li, Lidong Wang, Chunlin He, Yong Zhang, Jingya Yuan, Jingjing Luo, Xi Liu, Yu Xiu, Hang Li, Marina Gritsenko, Ernesto S. Nakayasu, Yue Feng, Zhao-Qing Luo, Nancy E. Freitag
One unique feature of L. pneumophila Dot/Icm effectors is the existence of protein families with members of high-level similarity. Whereas members of some families are functionally redundant, as suggested by their primary sequences, the relationship between SidJ and SdjA, the two members of the SidJ family, has remained mysterious.