Omics-LHV Profiling of Host Response to Influenza A Virus Infection Background: Influenza A viruses (IAV) are classified as a Category C priority pathogen, by the National Institute of Allergy and Infectious Diseases (NIAID), and are known to cause severe and even fatal infections in humans where...

Omics Lethal Human Virus, SARS-CoV Experiment SM001 New uploads pending The purpose of this experiment was to evaluate the human host response to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) wild-type virus. Sample data was obtained for 20 week-old C57BL/6J mouse lung tissue infected...

Reusable Digital Data Lifecycle Downloads for Omics-Lethal Human Virus Systems Biology The Omics-LHV Systems Virology project was one of four projects, funded by the NIAID Systems Biology for Infectious Diseases Research Program (funded from 2008-2013), was established in developing and validating...

Omics-LHV Systems Biology Modeling Host Response to Severe Acute Respiratory Syndrome (SARS) Infection The Systems Virology project was one of four systems biology contracts funded by the NIAID Systems Biology for Infectious Diseases Research Program from 2008-2013. The Systems Biology for...

Reusable Digital Data Lifecycle Downloads for Modeling Host Responses to Understand Severe Human Virus Infections The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host Responses to Understand Severe Human Virus Infections" (U19AI106772) program project was a highly...

Ebola Experiment EH001 Multi-platform omics analyses of peripheral blood mononuclear cells and plasma derived from human patients infected with Ebola ΔVP30 virus from Sierra Leone. Patients with fatal EVD succumbed to the infection before additional samples could be collected. In total, 29 samples...

Influenza A Experiment IM103 The purpose of this experiment was to evaluate the human host response to wild-type Influenza A/Vietnam/1203/2004 (H5N1; VN1203) virus infection and mock infection. Sample data was obtained for mouse lung tissue for mRNA, miRNA, proteomics, lipidomics, and metabolomics...

Influenza A Experiment IM102 The purpose of this Influenza experiment was to obtain samples for mRNA, miRNA, proteomics, lipidomics, and metabolomics analysis in mouse lung infected with WT A/Anhui/1/2013 (H7N9; 'AH1'), AH - NS1-103F/106M, and AH1 - 691 (ferret adapted virus). Overall Design: Groups...

Influenza A Experiment ICL104 The purpose of this experiment was to evaluate the host response to Influenza A pandemic wild-type H1N1 (A/California/04/2009), natural isolate virus. Sample data was obtained for human Calu-3 cells infected with wild-type H1N1 virus (A/California/04/2009) for mRNA...

Influenza A Experiment ICL103 The purpose of this experiment was to evaluate the human host response to Influenza A wild-type (H5N1) virus and mutant viruses. Sample data was obtained for human lung adenocarcinoma cell line (Calu-3) infected with WT Influenza A/Vietnam/1203/2004 (H5N1, VN1203) and...

Influenza A Experiment ICL102 The purpose of this experiment was to evaluate the human host cellular response to wild-type Influenza A/Anhui/1/2013 (H7N9; AH1) virus and mutant (NS1-L103F/I106M) virus infection. Sample data was obtained from human lung adenocarcinoma cells (Calu-3) for mRNA, miRNA...

Ebola Experiment EHUH001 The purpose of this experiment was to evaluate the human host response to Zaire Ebola wild-type virus and mutant virus infection. Samples were obtained from human hepatoma carcinoma cells (HUH-7) infected with Zaire Ebola ΔVP30-WT background, in addition to mutant viruses...

MERS-CoV Experiment MCL001 The purpose of this experiment was to evaluate the human host cellular response to wild-type Middle Eastern Respiratory Syndrome coronavirus (icMERS) and icMERS-CoV mutants icMERS-CoV-RFP, icMERS-CoV-dNSP16, icMERS-CoV-d4B, and icMERS-CoV-d3 virus infection. Sample time...

Interferon Experiment IFNaHUH001 The purpose of this experiment was to evaluate the human host cellular response to treatment with and without interferon alpha beta (IFNαβ) treatment. Sample time course data was obtained from human hepatoma carcinoma cells (HUH-7) expressing transcriptional...

Interferon Experiment IFNMVE001 The purpose of this experiment was to evaluate the host interferon-stimulated cellular response to human interferon alpha beta (IFNαβ) or gamma (INFγ) treatment. Sample data was obtained from human primary lung microvascular endothelial (MVE) cells treated with or...