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Person
Dr Peiyuan Gao

Dr. Gao obtained her Ph.D degree in Chemistry from institute of chemistry, Chinese Academy of Science. His Ph.D research focused on multiscale modeling of morphology and properties of polymeric materials, polymer processing and unveiling the process–properties relationships. (atomic to coarse...

Data Analytics & Machine Learning
Dr Peiyuan Gao
Publication
Micro-scale TMT Proteomics for Biomarker Discovery from Exhaled Breath Condensate in a Longitudinal Study

Exhaled breath condensate proteomics represent a low-cost, non-invasive alternative for examining upper respiratory health. EBC has previously been used for the discovery and validation of detected exhaled volatiles and non-volatile biomarkers of disease related to upper respiratory system distress...

Biology
Chemical & Biological Signatures Science
Human Health
Person
Paul Piehowski

Dr. Paul Piehowski is the Proteomics team leader for PNNL’s Environmental and Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. Piehowski is an analytical chemist whose research is focused on the application of mass spectrometry to biological...

Biology
Earth System Science
Paul Piehowski Portrait
Person
Sara JC Gosline
Sara Gosline received BA in Computer Science from Columbia University and spent two years working in software before returning to graduate school full time. She received her Masters and PhD in Computer Science from McGill University with a specialty in Bioinformatics and then moved to the...
Computational Research
Resource
Superfund Research Program Analytics Portal

The srpAnalytics modeling pipeline for the Superfund Research Program Analytics Portal.

Scientific Discovery
Biology
OSU-PNNL SRP
Publication
The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes

Citation: Gosline, S.J.C., Kim, D.N., Pande, P. et al. The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. Sci Data 10 , 151 (2023). https://doi.org/10.1038/s41597-023-02021-5 Funding Acknowledgments The research reported herein was...

Scientific Discovery
Biology
Human Health
Data Source
srpAnalytics

The srpAnalytics modeling pipeline for processing new data for the OSU-PNNL Superfund Research Program Analytics Portal located at https://github.com/sgosline/srpAnalytics Data License MIT License Copyright (c) 2020 Sara JC Gosline . Permission is hereby granted, free of charge, to any person...

Scientific Discovery
Biology
Project
OSU-PNNL Superfund Research Program Center

OSU-PNNL Superfund Research Program Center is part of the Superfund Research Program (SRP) at Oregon State University, directed by Dr. Robyn Tanguay, bringing together a multidisciplinary team of experts with extensive experience in polycyclic aromatic hydrocarbons (PAHs) research. Using state-of...

Scientific Discovery
Biology
Human Health

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Institution
National Institutes of Health
https://www.nih.gov/about-nih/what-we-do/mission-goals NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The goals of the agency are: to foster...
Biology
Human Health
NIH Logo
Publication
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
Biology
Human Health
Publication
Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Biology
Human Health
Publication
Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
Biology
Human Health
Publication
Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
Biology
Human Health
Publication
A comprehensive collection of systems biology data characterizing the host response to viral infection
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Biology
Human Health
Publication
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
Biology
Human Health