Publication - Journal Article The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes

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The OSU/PNNL superfund Research Program represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons at various superfund sites in the Pacific Northwest and assess their potential impact on human health.  To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental model of human exposure that provides quantitative measurements of the biological ramifications of exposure to toxicants. Toward this end, we have identified more than 1000 chemicals found at Superfund sites and measured the effect of these same chemicals in zebrafish, creating a rich dataset that links environmental exposure to phenotype. We have implemented a dose-response modeling pipeline to calculate benchmark dose parameters that enable the comparison of potency across chemicals and phenotypes.  Our portal provides public access to this dataset and an interactive web site designed to enable exploration and re-use of this data by the scientific community.