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The OSU/PNNL superfund Research Program represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons at various superfund sites in the Pacific Northwest and assess their potential impact on human health.  To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental model of human exposure that provides quantitative measurements of the biological ramifications of exposure to toxicants. The PNNL Superfund  have implemented a dose-response modelling pipeline to calculate benchmark dose parameters that enable the comparison of potency across chemicals and phenotypes.  Our portal provides public access to this dataset and an interactive web site designed to enable exploration and re-use of this data by the scientific community at


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Projects (1)
OSU-PNNL Superfund Research Program Center

Technical Documents

Publications (1)
The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes
People (3)

Sara Gosline received BA in Computer Science from Columbia University and spent two years working in software before returning to graduate school full time. She received her Masters and PhD in Computer Science from McGill University with a specialty in Bioinformatics and then moved to the...

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...

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Resources (1)