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Person
Sara JC Gosline
Sara Gosline received BA in Computer Science from Columbia University and spent two years working in software before returning to graduate school full time. She received her Masters and PhD in Computer Science from McGill University with a specialty in Bioinformatics and then moved to the...
Computational Research
Resource
Superfund Research Program Analytics Portal

The srpAnalytics modeling pipeline for the Superfund Research Program Analytics Portal.

Scientific Discovery
Biology
OSU-PNNL SRP
Publication
The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes

Citation: Gosline, S.J.C., Kim, D.N., Pande, P. et al. The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes. Sci Data 10 , 151 (2023). https://doi.org/10.1038/s41597-023-02021-5 Funding Acknowledgments The research reported herein was...

Scientific Discovery
Biology
Human Health
Data Source
srpAnalytics

The srpAnalytics modeling pipeline for processing new data for the OSU-PNNL Superfund Research Program Analytics Portal located at https://github.com/sgosline/srpAnalytics Data License MIT License Copyright (c) 2020 Sara JC Gosline . Permission is hereby granted, free of charge, to any person...

Scientific Discovery
Biology
Project
OSU-PNNL Superfund Research Program Center

OSU-PNNL Superfund Research Program Center is part of the Superfund Research Program (SRP) at Oregon State University, directed by Dr. Robyn Tanguay, bringing together a multidisciplinary team of experts with extensive experience in polycyclic aromatic hydrocarbons (PAHs) research. Using state-of...

Scientific Discovery
Biology
Human Health

  1. Datasets

    3
Institution
National Institutes of Health
https://www.nih.gov/about-nih/what-we-do/mission-goals NIH’s mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability. The goals of the agency are: to foster...
Biology
Human Health
NIH Logo
Publication
The Role of EGFR in Influenza Pathogenicity: Multiple Network-Based Approaches to Identify a Key Regulator of Non-lethal Infections
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
Biology
Human Health
Publication
Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Biology
Human Health
Publication
Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
Biology
Human Health
Publication
Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
Biology
Human Health
Publication
A comprehensive collection of systems biology data characterizing the host response to viral infection
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Biology
Human Health
Publication
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
Biology
Human Health
Publication
Validation of the Community Land Model Version 5 over the Contiguous United States (CONUS) using in-situ and remote sensing datasets
The Community Land Model (CLM) is an effective tool to simulate the biophysical and biogeochemical processes and their interactions with the atmosphere. Although CLM Version 5 (CLM5) constitutes various updates in these processes, its performance in simulating energy, water and carbon cycles over...
Atmospheric Science
Project
NIAID Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection Background The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host...

Biology
Human Health
Integrative Omics

  1. Datasets

    45
Publication
MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...
Biology
Human Health