Omics-Lethal Human Virus, Interferon-Stimulated Response Experiment IFNaHUH001

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Description

Interferon Experiment IFNaHUH001

The purpose of this experiment was to evaluate the human host cellular response to treatment with and without interferon alpha beta (IFNαβ) treatment. Sample time course data was obtained from human hepatoma carcinoma cells (HUH-7) expressing transcriptional activation protein VP30 (Q05323), stably transfected with the Ebola VP30 gene for enabling replication of VP30-deficient Ebola virus for transcriptome expression analysis.

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Transcriptomics

  • Expression profiling by array (mRNA) 

Linked Primary Data Accessions

BioProject Accession:  PRJNA417084

GEO Dataset Accession: GSE106522 (mRNA transcriptome response)

 

Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772 and is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Related References

  1. 10.1073/pnas.0708057105
  2. 10.1128/JVI.00074-09
English
Projects (2)
Omics-Lethal Human Virus, Interferon-Stimulated Response
NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program Processed Data
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...

Data Sources (1)
Institutions (1)