Project - Modelling Omics-Lethal Human Virus, Interferon-Stimulated Response

Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection

The OMICS-LHV project aimed to develop a comprehensive understanding of the host response to unique viruses that cause lethal infections in humans by using a systems biology approach, assembling a multidisciplinary team of researchers with expertise in virology, host genetics, advanced high throughput technologies, computational modeling, and data management.

Overarching approach:

1. Taking global measurements of changes in different host molecules in cells or tissues infected with a lethal human virus
2. Applied computational analysis and various modeling technique for making predictions about what was controlling the host infection response
3. Testing predictions to refine the viral host response models

The knowledge gained from this work is expected to provide a strong foundation for understanding the host response to lethal human virus pathogens, and could facilitate the development of improved strategies for intervening with lethal virus disease.

Experimental Factors

Host Organisms

• Homo sapiens

Processed Viral Data

Dataset downloads contain one or more statistically processed data files related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated with an Interferon-stimulated response experimental study. 

Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772, and is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Cite as: Anderson, Lindsey N, McDermott, Jason E, Waters, Katrina M, & Eisfeld, Amie. 2021. "PNNL DataHub Project Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection Post-Processed Data Package DOIs". United States. doi: 10.25584/LHVIFN/1786979. url: https://data.pnnl.gov/group/nodes/project/13060.