Omics-Lethal Human Virus, Interferon-Stimulated Response

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Principal Investigator


Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection

Data Reuse & Impact: Omics-LHV PNNL sub-projects provide a never before released comprehensive human interferon response collection of primary and secondary transformation multi-Omics data profiling a series of priority pathogen viral model studies for enhanced open access to project data lifecycle deliverables. Using a highly integrated and multidisciplinary approach, linked primary data and metadata supporting secondary normalization datasets, provide critical information necessary for research reproducibility and long-term preservation. Enabling on-demand data access for research community consumption and developer reuse, serves to support new mechanistic insights and discoveries into host-pathogen interactions for aiding future biohazard data preparedness efforts in emergency response to global health crises involving viral infection.

The knowledge gained from this work is expected to provide a strong foundation in facilitating a better understanding of the host response to virus infection for developing improved strategies for intervening with lethal virus disease, and unveiling mechanisms from highly collaborative state-of-the-art systems biology methodologies and unique data capture capabilities.


Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772, and is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Cite as

Anderson, Lindsey N, McDermott, Jason E, Waters, Katrina M, & Eisfeld, Amie. 2021. "PNNL DataHub Project Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection Post-Processed Data Package DOIs". United States. doi: 10.25584/LHVIFN/1786979. url:

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Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

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