Dataset - Genomics, Transcriptomics Multi-omics data compendium: Data package 4 (Pck004)

It consists of human islets treated for 48 h with cytokines (IFNγ, TNFα, and/or IL1β), thapsigargin (TG), brefeldin A (BFA), or DMSO for the control (CTRL) and submitted for single-cell RNA-seq (n=5) and single-nucleus multi-omics sequencing (snMultiomics-seq, n=1) (Table 1). In this study, cytokines were used to induce both ER stress and inflammation. TG was used to induce ER stress by inhibiting sarcoendoplasmic reticulum Ca2+ ATPase (SERCA), and BFA was used to induce ER and Golgi stress by inhibiting the transport of protein from the ER to the Golgi. Overall, this study was designed to mimic diabetic stress.

Data repository: GSE237448

Publication: PMID 38956087