Dataset - Proteomics, RNA-Seq (mRNA,miRNA) Multi-omics data compendium: Data package 8 (Pck008)

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β with or without difluoromethylornithine (DFMO) and submitted to RNA-seq and proteomics analysis (Table 1). DFMO is an inhibitor of ornithine decarboxylase (ODC), an enzyme of the polyamine pathway. Therefore, this treatment was done to study if inhibiting the polyamine synthesis improves β-cell dysfunction.

Data contributors:

Emily K. Sims: Department of Diabetes Immunology, Beckman Research Institute, City of Hope, Duarte, CA, USA.

Abhishek Kulkarni, Sarah Tersey &  Raghavendra G. Mirmir: Kovler Diabetes Center and Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.

Soumyadeep Sarkar, Raghavendra Mirmira, Ernesto S. Nakayasu: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354, USA.

Data repositories:

RNA-seq: GSE226888

Proteomics: MSV000091431

Publication: PMID 37918404