Dataset - RNA-Seq (mRNA,miRNA) Multi-omics data compendium: Data package 17 (Pck017)

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq (Table 1). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the polyamine pathway. Therefore, this treatment was performed to determine whether inhibiting polyamine synthesis via distinct enzymes improves β-cell dysfunction.

Data contributors:

Batoul Hammoud: Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA.

Sarah Tersey & Raghavendra Mirmira: Kovler Diabetes Center and Department of Medicine, The University of Chicago, Chicago, IL, 60637, USA.

Data repository: GSE242725

Publication: PMID 38195178