Dataset - Proteomics Multi-omics data compendium: Data package 20 (Pck020)

It consists of MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post RNAi targeting 85/88 kDa calcium-independent phospholipase A2 (Pla2g6) and submitted to proteomics analysis (Table 1). Pla2g6 is an enzyme that metabolizes phosphatidylcholine (PCs) into polyunsaturated fatty acids (PUFAs) like omega-3 fatty acids (omega-3 FAs), which protect β cells from cytokine-induced apoptosis. Therefore, this RNAi treatment was performed to determine the mechanism by which omega-3 FAs protect cytokine-induced β-cell death.

Data repository: PXD017863

Publication: PMID 38383396