Clinical Proteomic Tumor Analysis Consortium (CPTAC) ovarian cancer proteogenomics project. Characterization of tumors using proteomics and phosphoproteomics to identify signatures of drug resistance and characterize pathways associated with tumor versus normal tissue.

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to West Nile Virus Infection Background West Nile virus ( WNV ) belongs to the mosquito-borne Flaviviridae family and is classified as a Category A priority pathogen by the National Institute of Allergy and...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to Ebola Virus Infection Background Ebola virus ( EBOV ) is a high risk biological agent, belonging to the Flaviviridae family, and is classified as a Category A priority pathogen by the National Institute...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to MERS-CoV Virus Infection Background Middle East Respiratory Syndrome coronavirus ( MERS-CoV ), part of the Coronaviridae family, is classified as a Category C priority pathogen by the National Institute...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection Background The human host Interferon ( IFN ) alpha, beta, and gamma participate in the body's natural immune response to lethal virus infection and disease. The...

Some of the most rapid environmental changes on the planet are experienced in high-latitude regions. These changes affect all Earth system components, including the ocean, atmosphere, cryosphere, and marine and terrestrial ecosystems, and have both regional and global implications. The main...

The long-term goals of this scientific focus area (SFA) are to develop flexible and extensible modeling capabilities that capture the dynamic multiscale interactions among climate, energy, water, land, socioeconomics, critical infrastructure, and other sectors and to use these capabilities to study...

Neisseria gonorrhoeae is a Gram-negative diplococcus that is responsible for the sexually transmitted infection gonorrhea, a high morbidity disease in the United States and worldwide. Over the last several years N. gonorrhoeae strains resistant to antibiotics used to treat this infection have begun...

Accurate characterization of the global downward shortwave (SW) and photosynthetically active radiation (PAR) is fundamental for Earth system modeling and global change research. Combined with a machine-learning method, we used the Earth Polychromatic Imaging Camera (EPIC) data onboard the Deep...

The objective of Terrestrial-Aquatic Interface (TAI) research in PREMIS is to understand the factors governing C and nutrient movement and transformation through the TAI, and their sensitivities to inundation and salinity within coastal watersheds.

The EyeSea underwater video dataset was assembled for developing algorithms for detecting fish in real world underwater video data. The data were recorded as part of environmental monitoring efforts at three different water power sites.

The Predicting Ecosystem Resilience through Multiscale Integrative Science (PREMIS) database was generated to mechanistically understand how feedbacks across scales, from molecular to plant to plant populations and communities to ecosystems, govern the resilience of system functions to elevated CO2...

Tom Metz is a Principal Investigator within the Integrative Omics group at PNNL and the Metabolomics Team Lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. He has worked to develop state...

Aaron Wright leads the Chemical Biology & Exposure Sciences Group in the Biological Sciences Division at PNNL. His highly collaborative and diverse chemical biology research team is focused on gaining an improved functional and mechanistic understanding of biological processes including: (a)...

Hyun Song’s research is directed toward developing modeling and computational tools for the simulation of cellular metabolism and microbial community dynamics. His research interest in metabolic modeling includes 1) omics data-guided estimation of flux distribution in a genome-scale metabolic...