OmicsLHV-MMVE001

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Description

Omics-LHV, MERS

Experiment MMVE001

 

The purpose of this MERS experiment was to obtain samples for omics analysis in primary human microvascular endothelial cells infected with wild type MERS-CoV (icMERS).

Overall Design: Human airway epithelial cells were infected in a multiplicity of 5 PFU per cell. Infected samples were collected in quintuplet and time-matched with mocks samples in parallel. Sample time points used were:  0, 12, 24, 36, and 48 hrs post-infection.

MERSCOV002.0P references the write up of the experimental procedure.

Processed Omics Data (available at download button):

Dataset downloads contain one or more statistically processed data file related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated with an icMERS experimental study. 

 

Transcriptomics

mRNA

miRNA

Proteomics

Lipidomics

Metabolomics

Related Experimental Data

BioProject:  PRJNA315199PRJNA315195

GEO:  GSE79218 (mRNA transcriptome response), GSE79216 (mRNA transcriptome response)

MassIVE: MSV000081047 (lipidome response), MSV000079702 (metabolome response), MSV000079703 (proteome response)

English
Projects (2)
Omics-Lethal Human Virus, MERS-CoV
NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program Processed Data
Publications (1)
Unfolded Protein Response Inhibition Reduces Middle East Respiratory Syndrome Coronavirus-Induced Acute Lung Injury
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...