Omics-Lethal Human Virus, Influenza A Experiment ICL104

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Influenza A Experiment ICL104

The purpose of this experiment was to evaluate the host response to Influenza A pandemic wild-type H1N1 (A/California/04/2009), natural isolate virus. Sample data was obtained for human Calu-3 cells infected with wild-type H1N1 virus (A/California/04/2009) for mRNA, miRNA, proteomics, lipidomics, and metabolomics analysis. 

Accessible Multi-Omics Digital Data Downloads

Secondary host-associated viral dataset downloads contain one or more qualitative and/or quantitative statistically processed (normalization data transformation) expression analysis file(s) resulting from primary viral experimental study designs leveraging unique high-resolution Omics capabilities. Proteomic, metabolomic, lipidomic, and/or transcriptomics dataset downloads each have a direct relationship to a primary sample data submission corresponding to a specific Influenza A host infection.


  • Expression profiling by array (mRNA) 
  • Non-coding RNA profiling by array (miRNA)

Proteomics, Metabolomics, Lipidomics

  • Protein quantification by liquid chromatography mass spectrometry (LC-MS)
  • Metabolite quantification by gas chromatography mass spectrometry (GC-MS)
  • Lipid quantification by liquid chromatography mass spectrometry (LC-MS)

Linked Primary Data Accessions

BioProject Accession: PRJNA319727

GEO Accession: GSE80697 (mRNA transcriptome response), GSE80698 (miRNA transcriptome response)

MassIVE Accession:  MSV000081049 (lipidome response),  MSV000080026 (proteome response), MSV000079704 (metabolome response)


Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772, and is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Projects (2)
Omics-Lethal Human Virus, Influenza A
NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program Processed Data
Publications (2)
MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...

Data Sources (3)