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Omics-LHV, West Nile

Experiment WCT001


The purpose of this West Nile experiment was to obtain samples for omics analysis in mouse cortex tissue infected with wild-type West Nile Virus (WNV; WNV-NY99 382), and mutant WNV-E218A (WNV-NY99 382 E218A 2 nt).

Overall Design: Mice were inoculated with WNV intracranially at a dose of 100 FFU. Infected samples were then collected in quintuplet in addition to time-matched mocks in parallel with infected samples. Time points used were: 1, 2, 4, and 6 days post-infection. Tissues from this experiment were matched to tissues from GSE77192 (WCB001), using 1/4 of the cortex and 1/2 of cerebellum from the same mice.

Processed Omics Data (available at download button):

Dataset downloads contain one or more statistically processed data file related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated with a West Nile experimental study. 








Related Experimental Data

BioProject:  PRJNA309682PRJNA309680

GEO:  GSE77193 (mRNA transcriptome response), GSE77161 (miRNA transcriptome response)

MassIVE:  MSV000081048 (lipidome response), MSV000080019 (metabolome response), MSV000080361 (proteome response)

Projects (2)
Omics-Lethal Human Virus, West Nile
NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program Processed Data
Publications (1)
Hypergraph models of biological networks to identify genes critical to pathogenic viral response
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...