Dataset - Omics, Proteomics, Metabolomics Omics-Lethal Human Viruses, West Nile Experiment WSE001

https://doi.org/10.25584/LHVWSE001/1661962
Biology
Human Health
Integrative Omics
Virology
Immune Response
West Nile virus
Multi-Omics
Mass spectrometry data
Differential Expression Analysis

Last updated on 2023-01-30T00:09:57+00:00 by LN Anderson

West Nile virus Experiment WSE001

The purpose of this experiment was to evaluate the mouse (C57BL6/JAX) mock-treated ("Koolaid") and/or drug treated (3Abx; Ampicillin, Vancomycin, and Neomycin) host response to wild-type West Nile virus (WNV-NY99, 382) infection. Sample data was obtained from mouse serum and processed for proteomics and metabolomics expression analysis.

Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Leveraging unique high-resolution Omics capabilities for proteomics and metabolomics each dataset download has a direct relationship to a primary sample corresponding to a specific West Nile virus infection.

Accessible Secondary Digital Data Downloads

Proteomics, Metabolomics, Lipidomics

  1. Protein quantification by liquid chromatography mass spectrometry (LC-MS)
  2. Metabolite quantification by gas chromatography mass spectrometry (GC-MS)

Linked Primary Data Accessions

MassIVE Accession: MSV000091193 (proteome response), MSV000091199 (metabolome response)

Raw Measurement Data DOI: 10.25345/C51J97J2S (proteome), 10.25345/C5CR5NP07 (metabolome)

MassIVE dataset license: CC0 1.0 Universal (CC0 1.0)

 

Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772 and is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

Citation Policy

In efforts to enable discovery, reproducibility, and reuse of NIH-funded project dataset citations, we ask that all reuse of project data and metadata download materials acknowledge all primary and secondary dataset citations where applicable and direct corresponding journal articles (Grant U19AI106772) where allowable in accordance with best practices outlined by the FORCE11 Joint Declaration of Data Citation Principles in alignment with NIH acknowledgement requirements (NOT-OD-21-013).

Data Licensing

CC BY-SA 4.0 (secondary dataset download DOIs), CC0 1.0 (project metadata and PNNL DataHub policy default), 

 

English
Projects (2)
Omics Lethal Human Viruses Project Profiling of the Host Response to West Nile Virus Infection, Processed Experimental Dataset Catalog
NIAID Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collections
People (3)
Lindsey N. Anderson

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Jason McDermott

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Katrina Waters

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...