New Onset Type 1 Diabetes Urine Metabolomics

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Description

Gas chromatography-mass spectrometry-based metabolomics to identify molecular signatures of Type 1 Diabetes (T1D) in urine. We utilize three cohorts in different stages post-diagnosis: (1) new onset, (2) within one year of diagnosis and (3) after 6 years of diagnosis.

There were 91 metabolites identified in all three datasets with complete data represented in each cohort dataset.

Cohort 1 (CNMC):

  • 32 T1D cases; 32 healthy controls siblings

Cohort 2 (BDCD):

  • 27 T1D cases; 27 healthy controls siblings

Cohort 3 (IUSOM):

  • 12 T1D cases; 20 healthy controls
  • Cases and controls matched on sex and age
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