Transcriptome and Redox Proteome Reveal Temporal Scales of Carbon Metabolism Regulation in Model Cyanobacteria Under Light Disturbance (pre-print)

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Primary publication pre-print.

Cite as: arXiv:2410.09346 [q-bio.MN]

Projects (5)

The Predictive Phenomics Science & Technology Initiative at Pacific Northwest National Laboratory are tackling the grand challenge of understanding and predicting phenotype by identifying the molecular basis of function and enable function-driven design and control of biological systems. Explore...

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The research goal of this project is to develop new theory and tools that leverage evolutionary perspectives and knowledge of the energetics of reactions to predict the most likely regulation in a given environment. These methods will accelerate exploration, modeling and understanding of cell...

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    3

We are constructing a streamlined approach to identify phenotype-relevant signatures by integrating various proteomics data. Leveraging protein structures and interaction networks, we will map structural changes and post-translational modifications to identify molecular drivers and subsequently...

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The research objective of this project is to develop an integrative and automated multi-PTM profiling capability with deep proteome coverage.

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The research goal of this project is to establish model synthetic microbial communities to understand the rules regulating their biological function in order to utilize them as next generation bioproduction platforms capable of reducing carbon and nitrogen footprints in biomanufacturing processes.

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People (4)

Margaret S. Cheung is a biological physicist and a computational scientist on the Computing, Analytics, and Modeling team at EMSL. She graduated from the National Taiwan University in 1994 and went on to obtain a Ph.D. degree from the University of California at San Diego in 2003. She was then...

In general, I am interested in studying complex systems by integrating both mechanism-based and data-driven approaches, in order to understand their dynamics, evolution, control, and design. The ultimate goal is to understand (some of) the design principles of complex systems, whether it is physical...

Dr. Tong Zhang is a scientist in the Biological Sciences Division at the Pacific Northwest National Laboratory (PNNL). His research focuses on using mass spectrometry-based proteomics to understand fundamental biology and improve human health. His current projects include developing redox proteomics...

Dr. Bohutskyi’s research focus is in developing new bioprocesses addressing sustainable transformation of carbon dioxide, biomass, and wet or liquid waste, including carbon, nitrogen, phosphorus, and other critical elements into bioproducts, chemicals, and fuels. This research uses a suite of...