Soil microorganisms play fundamental roles in cycling of soil carbon, nitrogen, and other nutrients, yet we have a poor understanding of how soil microbiomes are shaped by their nutritional and physical environment. In this study, we investigated the successional dynamics of a soil microbiome during...
Filter results
Tags
- (-) Health (23)
- (-) sequencing (13)
- (-) Genomics (12)
- (-) Proteomics (8)
- Virology (79)
- Immune Response (53)
- Time Sampled Measurement Datasets (50)
- Gene expression profile data (47)
- Differential Expression Analysis (46)
- Homo sapiens (34)
- Mass spectrometry data (31)
- Multi-Omics (30)
- Viruses (26)
- Omics (25)
- Virus (23)
- Soil Microbiology (21)
- MERS-CoV (18)
- Mus musculus (18)
- Mass Spectrometry (14)
- Synthetic (14)
- West Nile virus (13)
- Ebola (11)
- Influenza A (11)
- PerCon SFA (10)
- High Throughput Sequencing (9)
- Metagenomics (9)
- Resource Metadata (9)
- Microbiome (8)
- Machine Learning (7)
- Microarray (7)
Showing 1 - 15 of 59
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...
Category
Publication
The novel fungal strain, Fusarium sp. DS 682, was isolated from the rhizosphere of the perennial grass, Bouteloua gracilis , at the Konza Prairie Biological Station in Kansas. This fungal strain is common across North American grasslands and is resilient to environmental fluctuations. The draft...
Category
Publication
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...
Category
As part of the Pacific Northwest National Laboratory’s (PNNL) Science Focus Area program, we are investigating the impact of environmental change on microbial community function in grassland soils. Three grassland soils, representing different moisture regimes, were selected for ultra-deep...
Category
The soil microbiome is central to the cycling of carbon and other nutrients and to the promotion of plant growth. Despite its importance, analysis of the soil microbiome is difficult due to its sheer complexity, with thousands of interacting species. Here, we reduced this complexity by developing...
Category
Publication
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Category
The severe acute respiratory syndrome coronavirus accessory protein ORF6 antagonizes interferon signaling by blocking karyopherin-mediated nuclear import processes. Viral nuclear import antagonists, expressed by several highly pathogenic RNA viruses, likely mediate pleiotropic effects on host gene...
Category
Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
Category
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
Category
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Category
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...
Category
Dataset
Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from KPBS field site in Manhattan, KS. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.
Category
Dataset
Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from COBS field site in Boone County, IA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.
Category
Dataset
Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from IAREC field site in Prosser, WA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.