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Publication
A comprehensive collection of systems biology data characterizing the host response to viral infection
The Systems Biology for Infectious Diseases Research program was established by the U.S. National Institute of Allergy and Infectious Diseases to investigate host-pathogen interactions at a systems level. This program generated 47 transcriptomic and proteomic datasets from 30 studies that...
Biology
Human Health
Publication
A Network Integration Approach to Predict Conserved Regulators Related to Pathogenicity of Influenza and SARS-CoV Respiratory Viruses
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
Biology
Human Health
Project
NIAID Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson PNNL DataHub NIAID Program Project: Modeling Host Responses to Understand Severe Human Virus Infections, Multi-Omic Viral Dataset Catalog Collection Background The National Institute of Allergy and Infectious Diseases (NIAID) "Modeling Host...

Biology
Human Health
Integrative Omics

  1. Datasets

    45
Publication
MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of...
Biology
Human Health
Publication
Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis
The pathogenesis of human Ebola virus disease (EVD) is complex. EVD is characterized by high levels of virus replication and dissemination, dysregulated immune responses, extensive virus- and host-mediated tissue damage, and disordered coagulation. To clarify how host responses contribute to EVD...
Biology
Human Health
Person
Katrina Waters
Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...
Biology
Human Health
Publication
Terabase Metagenome Sequencing of Grassland Soil Microbiomes
As part of the Pacific Northwest National Laboratory’s (PNNL) Science Focus Area program, we are investigating the impact of environmental change on microbial community function in grassland soils. Three grassland soils, representing different moisture regimes, were selected for ultra-deep...
Earth System Science
Biology
Data Source
Illumina MiSeq System Sequencer

The Illumina MiSeq System Sequencer is a high-throughput DNA sequencer machine developed and manufactured by Illumina , and is designed for sequencing data acquisition using synthesis technology to provide an end-to-end solution (cluster generation, amplification, sequencing, and data analysis) in a...

Scientific Discovery
Biology
Microbiome Science
Earth System Science
Project
PNNL Soil Microbiome SFA

The Phenotypic Response of the Soil Microbiome to Environmental Perturbations Project (Soil Microbiome SFA) at Pacific Northwest National Laboratory is a Genomic Sciences Program Science Focus Area (SFA) Project operating under the Environmental Microbiome Science Research Area. The Soil Microbiome...

Biology
Microbiome Science
Earth System Science

  1. Datasets

    23