It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table S1 ) Data contributors: Ernesto S. Nakayasu, Jennifer E. Kyle, Young-Mo Kim, Soumyadeep Sarkar & Thomas O. Metz...

The data package consists of RNA-seq datasets of EndoC-βH1 cells treated in parallel with IFNα, IFNγ, IL-1β and TNFα for 24 h and submitted to RNA-seq (n=4) ( Table S1 ) Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty...

This data package consists of data from paired human islets treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), UMI-4C18 (n=2 or 3, depending on the viewpoint), and ChIP-seq for histone H3 lysine 27 acetylation (H3K27Ac) (n=4) ( Table S1 ). Islets across the study...

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq ( Table S1 ). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the...

This data package consists of data from human islets (n=6) treated with IFNγ + IL-1β for 24 h and subjected to top-down proteomics ( Table S1 ). Data contributors: Ashley N. Ives, Wei-Jun Qian & James M. Fulcher: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA...

This data package consists of data from human islets and EndoC-βH1 cells treated with IFNα for 2, 8, or 24 h and submitted to RNA-seq (human islets: n=6 & EndoC-βH1: n=5) and ATAC-seq (n=4). In parallel, a batch of cells (n=4) had proteomics, lipidomics, and metabolomics performed in the same...

This data package consists of data from MIN6 cells treated with IL-1β + IFNγ + TNFα + palmitate for 24 h and submitted to proteomics analysis, and the same treatment for 8 h for metabolomics analysis (n=4) ( Table S1 ). This experimental design was set to study the possible roles of free fatty acids...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5), and H3K27Ac ChIP-seq (n=4). In addition...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post RNAi targeting 85/88 kDa calcium-independent phospholipase A2 ( Pla2g6 ) and submitted to proteomics analysis ( Table S1 ). Pla2g6 is an enzyme that metabolizes phosphatidylcholine (PCs) into...

This data package consists of data from human islets treated for 48 h with cytokines (IFNγ, TNFα, and/or IL1β), thapsigargin (TG), brefeldin A (BFA), or DMSO for the control (CTRL) and submitted for single-cell RNA-seq (n=5) and single-nucleus multi-omics sequencing (snMultiomics-seq, n=1) ( Table...

This data package consists of RNA-seq data from human islets (n=10) treated with IFNγ + IL-1β for 24 h ( Table S1 ). Data contributors: Wenting Wu & Carmella Evans-Molina: Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. Farooq Syed: Center...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β with or without difluoromethylornithine (DFMO) and submitted to RNA-seq and proteomics analysis ( Table S1 ). DFMO is an inhibitor of ornithine decarboxylase (ODC), an enzyme of the polyamine pathway. Therefore...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq analysis ( Table S1 ). Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles...

Please cite as : Mary S. Lipton, William C. Nelson, Hugh McCullough, Montana L. Smith, Sheryl L. Bell, Lisa M. Bramer, Hyun-Seob Song, Kirsten Hofmockel, 2025. Moisture Metaphenome Incubation Analysis Results . [Data Set] PNNL DataHub. https://doi.org/10.25584/3007775 This data is published under a...

RhizoGrid Indexed Sorghum Rhizosphere Multi-Omics Identification of spatially resolved biomarkers of drought in Sorghum bicolor rhizosphere molecular-microbe interactions using a novel root cartography "RhizoGrid" system for sampling plants under drought and control conditions across 10 equally...