Omics-Lethal Human Virus, Ebola Experiment EH001

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Description

Ebola Experiment EH001

Multi-platform omics analyses of peripheral blood mononuclear cells and plasma derived from human patients infected with Ebola ΔVP30 virus from Sierra Leone. Patients with fatal EVD succumbed to the infection before additional samples could be collected. In total, 29 samples were obtained from 11 EVD survivors and 9 samples from 9 EVD fatalities. For comparison, we collected blood samples from 10 healthy volunteers. 

Processed Omics Data (available at download button):

Dataset downloads contain one or more statistically processed data files related to a lipidomic, transcriptomic, metabolomic, and/or proteomic dataset collection associated a Ebolavirus experimental study. 

Transcriptomics

  • Expression profiling by array (mRNA) 
  • Non-coding RNA profiling by array (miRNA)

Proteomics

  • Protein quantification by liquid chromatography mass spectrometry (LC-MS)

Lipidomics

  • Lipid quantification by liquid chromatography mass spectrometry (LC-MS)

Metabolomics

  • Metabolite quantification by liquid chromatography mass spectrometry (GC-MS)

 

Related Experimental Data

BioProject:  PRJNA208871PRJNA362617

GEO:  GSE93861 (PBL expression response of health care worker in Sierra Leone), GSE48080 (PBMCs response of septic patients with pneumonia)

MassIVE: MSV000080129 (lipidome, proteome, and metabolome response)

 

Acknowledgment of Federal Funding

The data described here was funded in whole or in part by the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health under award number U19AI106772, as a  is a contribution of the "Modeling Host Responses to Understand Severe Human Virus Infections" Project at Pacific Northwest National Laboratory. Data generated by the Omics-LHV Core for proteomics, metabolomics, and lipidomics analyses for were performed at Pacific Northwest National Laboratory in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the Department of Energy’s (DOE) Office, operating under the Battelle Memorial Institute for the DOE under contract number DE-AC05-76RLO1830. 

English
Projects (2)
Omics-Lethal Human Virus, Ebola
NIAID Modeling Host Responses to Understand Severe Human Virus Infections Research Program Processed Data
Publications (1)
Multi-platform ’Omics Analysis of Human Ebola Virus Disease Pathogenesis
People (3)

Lindsey Anderson’s research has been dedicated to the identification and characterization of novel, targeted and non-targeted, functional metabolic interactions using a high-throughput systems biology and computational biology approach. Her expertise in functional metabolism and multidisciplinary...

Dr. Jason McDermott, senior research scientist, has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology. Currently, his research interests include data...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...