Data Source - Instrument Q Exactive Plus Mass Spectrometer

Last updated on 2025-02-03T23:25:06+00:00 by LN Anderson

The Thermo Scientific™ Q Exactive™ Plus Mass Spectrometer benchtop LC-MS/MS system combines quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection to deliver exceptional performance and versatility. Quadrupole technology optimizes precursor selection and transmission, improving quantitation of low-abundance ions in the most complex matrices. Sophisticated parallel reaction monitoring and data independent analysis provide reproducible quantitation results while delivering complete qualitative confidence. An optional intact protein mode enhances analysis of intact proteins through sophisticated ion beam control and easy collision pressure adjustment, while optional 280,000 maximum resolving power ensures superior ID confidence. The Q Exactive Mass Spectrometer is equally useful for un-targeted or targeted screening and a broad range of qualitative and quantitative applications in top-down proteomics and Lipidomics applications.

Data Source Contributions

• LN Anderson, Data Curation
• RJ Moore, Resource Review

Instrument Data Source Profile

Instrument Name:      Q Exactive Plus

Model:                         Thermo Scientific™ Q Exactive™ Plus Mass Spectrometer

Platform:                     LC-HMS with MS/MS; optional HCD capabilities

Data Types:                 DIA-HMS-HCD-HMSn, HMS, HMS-HCD-HMSn, HMS-HMSn

Instrument Group:      Liquid Chromatography Mass Spectrometry

Topic Areas:                Omics, Proteomics, Lipidomics

Explore this capability and more at the Environmental Molecular Sciences Laboratory (EMSL) Bottom-Up (fragmented) Proteomics and Lipidomics instrument resource page. For a list of complimentary mass spectrometry data process software and analytical workflows, visit https://zenodo.org/communities/pnnl. 

Federal Acknowledgements

This work was supported in part by the Earth and Biological Sciences Directorate (EBSD) at Pacific Northwest National Laboratory (PNNL), a multiprogram national laboratory managed by the Battelle Memorial Institute, operating under the U.S. Department of Energy (DOE) contract DE-AC05-76RL01830. User capabilities described here reflect collaborations with the Environmental Molecular Sciences Laboratory (EMSL), a DOE Office of Science (SC-3) user facility operating under the Contract No. DE-AC05-76RL01830.

Terms of Use

Recommendation guidelines provided by the DOE Office of Science can be accessed at the SC Funding Opportunities & Acknowledgements homepage. For additional information regarding user capability data release, visit the SC Digital Data Management Resources at User Facilities for more information.

EMSL Funding Acknowledgment

Scientists who publish results of research using EMSL resources, capabilities, and resulting data are required to include an acknowledgment of EMSL Policies in any publications. Learn more about user facility data management resources at the Office of Science Program page.