This data is a model of synthetic adversarial activity surrounded by noise and was funded by DARPA. The various versions include gradually more complex networks of activities. This data was generated by PNNL. Activities can be phone calls, transactions, or any other type of communications. Most of...

Some of the most rapid environmental changes on the planet are experienced in high-latitude regions. These changes affect all Earth system components, including the ocean, atmosphere, cryosphere, and marine and terrestrial ecosystems, and have both regional and global implications. The main...

The Diabetes Autoimmunity Study in the Young (DAISY) seeks to find environmental factors that can trigger the development of type 1 diabetes (T1D) in children. DAISY follows children with high-risk of developing T1D based on family history or genetic markers. Genes, diets, infections, and...

Machine learning is a core technology that is rapidly advancing within type 1 diabetes (T1D) research. Our Human Islet Research Network (HIRN) grant is studying early cellular response initiating β cell stress in T1D through the generation of heterogenous low- and high-throughput molecular...

Predictive Phenomics is addressing the grand challenge of understanding and predicting phenotype by identifying the molecular basis of function and enable function-driven design and control of biological systems .

The Human Islet Research Network (HIRN) is a large consortia with many research projects focused on understanding how beta cells are lost in type 1 diabetics (T1D) with a goal of finding how to protect against or replace the loss of functional beta cells. The consortia has multiple branches of...

PNNL Publications 2020 Smith J.N., K.J. Tyrrell, J.P. Smith, J.P. Smith, K.K. Weitz, and W.D. Faber. 2020. "Linking Internal Dosimetries of the Propyl Metabolic Series in Rats and Humans Using Physiologically Based Pharmacokinetic (PBPK) Modeling." Regulatory Toxicology and Pharmacology 110. PNNL...

PNNL Publications 2020 Ogden A.J., T.W. Wietsma, T.E. Winkler, Y. Farris, G.L. Myers, and A. Ahkami. 2020. "Dynamics of Global Gene Expression and Regulatory Elements in Growing Brachypodium Root System." Scientific Reports 10. PNNL-SA-145907. doi:10.1038/s41598-020-63224-z 2019 Boiteau R.M., S.J...

Publications: 2018 Khan NE, Y Maezato, RS McClure, CJ Brislawn, JM Mobberley, NG Isern, WB Chrisler, LM Markillie, BM Barney, HS Song, WC Nelson, and HC Bernstein. 2018. "Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture." Scientific...

Michelle Davison is a microbiologist with a love of challenging, creative, and multidisciplinary projects. She is interested in the role phage play in environmental systems, as well as the myriad ways they can be harnessed as tools. She has experience isolating, developing and working with non-model...

Biography Kristin Burnum-Johnson is a senior scientist and team lead of the Biomolecular Pathways team at PNNL. Burnum-Johnson earned her PhD in Biochemistry from Vanderbilt University with Professor Richard M. Caprioli and then completed a postdoctoral fellowship at PNNL with Dr. Richard D. Smith...

Biography Young-Mo Kim is a senior bioanalytical chemist at PNNL. He received his PhD from Pohang University of Science and Technology in the School of Environmental Science and Engineering, studying analysis of metabolites during the bacterial and fungal degradation of xenobiotic substrates using...

Short Biography Caroline (Carrie) Harwood received her Ph.D. in microbiology from the University of Massachusetts and completed postdoctoral work at Yale University. She held academic appointments at Cornell University and the University of Iowa before moving to the University of Washington in 2005...

Biography Ernesto Nakayasu is a senior research scientist focused on understanding molecular mechanisms of diseases. Nakayasu has been applying systems biology and mass spectrometry-based omics measurements to study how pathogens and metabolic alterations cause human diseases; the goal is to...

Dr. Katrina Waters is the division director for Biological Sciences at the Pacific Northwest National Laboratory. Waters has a Ph.D. in biochemistry and more than 15 years of experience in microarray and proteomics data analysis. Her research interests are focused on the integration of genomics...