Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Interferon-Stimulated Response to Virus Infection Background The human host Interferon ( IFN ) alpha, beta, and gamma participate in the body's natural immune response to lethal virus infection and disease. The...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to MERS-CoV Virus Infection Background Middle East Respiratory Syndrome coronavirus ( MERS-CoV ), part of the Coronaviridae family, is classified as a Category C priority pathogen by the National Institute...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to Ebola Virus Infection Background Ebola virus ( EBOV ) is a high risk biological agent, belonging to the Flaviviridae family, and is classified as a Category A priority pathogen by the National Institute...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to Influenza A Virus Infection Background Influenza A virus ( IAV ) is a high risk biological agent belonging to the Orthomyxoviridae family is classified as a Category C priority pathogen by the National...

Last updated on 2024-02-11T22:41:43+00:00 by LN Anderson Omics-LHV Profiling of Host Response to West Nile Virus Infection Background West Nile virus ( WNV ) belongs to the mosquito-borne Flaviviridae family and is classified as a Category A priority pathogen by the National Institute of Allergy and...

Spruce and Peatlands Responses Under Changing Environments (SPRUCE) site is the 8.1-ha S1 bog, a Picea mariana [black spruce] – Sphagnum spp. ombrotrophic bog forest in northern Minnesota, 40 km north of Grand Rapids, in the USDA Forest Service Marcell Experimental Forest (MEF). Two field research...

The Biomedical Resilience & Readiness in Adverse Operating Environments (BRAVE) Project develop new capabilities to improve health and performance of first responders in adverse operating environments common to national defense. The BRAVE project analyze biological samples, collect physiological...

Machine learning is a core technology that is rapidly advancing within type 1 diabetes (T1D) research. Our Human Islet Research Network (HIRN) grant is studying early cellular response initiating β cell stress in T1D through the generation of heterogenous low- and high-throughput molecular...

Clinical Proteomic Tumor Analysis Consortium (CPTAC) ovarian cancer proteogenomics project. Characterization of tumors using proteomics and phosphoproteomics to identify signatures of drug resistance and characterize pathways associated with tumor versus normal tissue.

Coastal landscapes are increasingly exposed to seawater due to sea level rise and extreme weather events. The biogeochemical responses of these vulnerable ecosystems are poorly understood, limiting our ability to predict how their role in global biogeochemical cycles will shift under future...

Michelle Davison is a microbiologist with a love of challenging, creative, and multidisciplinary projects. She is interested in the role phage play in environmental systems, as well as the myriad ways they can be harnessed as tools. She has experience isolating, developing and working with non-model...

Publications: 2018 Khan NE, Y Maezato, RS McClure, CJ Brislawn, JM Mobberley, NG Isern, WB Chrisler, LM Markillie, BM Barney, HS Song, WC Nelson, and HC Bernstein. 2018. "Phenotypic responses to interspecies competition and commensalism in a naturally-derived microbial co-culture." Scientific...

PNNL Publications 2020 Smith J.N., K.J. Tyrrell, J.P. Smith, J.P. Smith, K.K. Weitz, and W.D. Faber. 2020. "Linking Internal Dosimetries of the Propyl Metabolic Series in Rats and Humans Using Physiologically Based Pharmacokinetic (PBPK) Modeling." Regulatory Toxicology and Pharmacology 110. PNNL...

Short Biography Caroline (Carrie) Harwood received her Ph.D. in microbiology from the University of Massachusetts and completed postdoctoral work at Yale University. She held academic appointments at Cornell University and the University of Iowa before moving to the University of Washington in 2005...

Dr. Joshua Elmore is a Chemical Engineer at Pacific Northwest National Laboratory. He received his Ph. D. from the University of Georgia in the Department of Molecular Biology and Biochemistry studying the mechanisms of CRISPR/Cas microbial immune systems in hyperthermophilic Archaea. He was a...