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Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and...
Respiratory infections stemming from influenza viruses and the Severe Acute Respiratory Syndrome corona virus (SARS-CoV) represent a serious public health threat as emerging pandemics. Despite efforts to identify the critical interactions of these viruses with host machinery, the key regulatory...
The broad range and diversity of interferon-stimulated genes (ISGs) function to induce an antiviral state within the host, impeding viral pathogenesis. While successful respiratory viruses overcome individual ISG effectors, analysis of the global ISG response and subsequent viral antagonism has yet...
Despite high sequence similarity between pandemic and seasonal influenza viruses, there is extreme variation in host pathogenicity from one viral strain to the next. Identifying the underlying mechanisms of variability in pathogenicity is a critical task for understanding influenza virus infection...

Viral genome assembly annotations from terabase metagenomes (TmG.1.0) from uncultivated soil collections from the IAREC field sites in Washington (IAREC), Kansas (KBPS), and Iowa (COBS), USA. Uncultivated virus Genomes (identified from soil metagenome datasets) Data DOI Package.

Exhaled breath condensate proteomics represent a low-cost, non-invasive alternative for examining upper respiratory health. EBC has previously been used for the discovery and validation of detected exhaled volatiles and non-volatile biomarkers of disease related to upper respiratory system distress...

The continual growth in energy demand has resulted in the deployment of renewable energy generators to reduce the impact of fossil fuel dependence. However, these generators often suffer from intermittency and require energy storage when there is over-generation and the subsequent release of this...

Viral communities detected from three large grassland soil metagenomes with historically different precipitation moisture regimes.

Dataset

Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from KPBS field site in Manhattan, KS. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.

Dataset

Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from COBS field site in Boone County, IA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.

Dataset

Complete replicate terabase metagenome (TmG.2.0) of grassland soil microbiome collections from IAREC field site in Prosser, WA. Metagenome (unclassified soil sequencing) Data DOI Package, version 2.0.

Viral communities detected from three large grassland soil metagenomes with historically different precipitation moisture regimes.

Many important application data streams can be modeled as a complex graph of entities, where each graph node or entity is associated with a multi-variate time-series. The overall system’s behavior is modeled as a dynamical system, and it evolves through structural changes in the graph, and/or...

  1. Datasets

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GridSTAGE (Spatio-Temporal Adversarial scenario GEneration) is a framework for the simulation of adversarial scenarios and the generation of multivariate spatio-temporal data in cyber-physical systems. GridSTAGE is developed based on Matlab and leverages Power System Toolbox (PST) where the...

Soil fungi facilitate the translocation of inorganic nutrients from soil minerals to other microorganisms and plants. This ability is particularly advantageous in impoverished soils, because fungal mycelial networks can bridge otherwise spatially disconnected and inaccessible nutrient hotspots...