The files for this dataset are available at: https://doi.org/10.25584/17172447 The National Environmental Policy Act of 1969, as amended (NEPA), is a major environmental law in the United States, requiring Federal agencies to consider and document potential environmental impacts before deciding on a...

This study aimed to quantify rates of viral production in aridisol soil under conditions as close to natural field soil as possible given the perturbations necessary to manipulate viral abundances. Viruses were removed from soil, then added back to virus-depleted soil to control the initial viral...

Fluorescently tagged bacterial soil isolates were cultured with N-acetylglucosamine, chitopentose, or chitin in porous SoilChip devices designed to mimic the structural habitats found in soil. Imaging analysis was used to examine how microbial traits, nutrient substrate solubility and degree of...

The data package consists of isolated pancreatic islets from adult male C57BL6/J mice treated with IL-1β, IFNγ or IL-1β + IFNγ for 6 h and submitted for scRNA-seq ( Table S1 ). This study focused on understanding the heterogeneity of the cytokine-mediated response. Data contributors: Jennifer S...

This data package consists of data from β-TC-6 cells treated with IFNγ + IL-1β for 4, 8 or 24 h (n=4) and submitted to enrichment of cysteine-containing peptides (redox), phosphopeptides and acetylated peptides. This enabled the analysis of proteomics, redox cysteine, phosphoproteomics and...

It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table S1 ) Data contributors: Ernesto S. Nakayasu, Jennifer E. Kyle, Young-Mo Kim, Soumyadeep Sarkar & Thomas O. Metz...

This data package consists data from EndoC-βH1 (n=6) treated with IFNα for 8 and 24 h and submitted to RNA-seq analysis ( Table S1 ). This was generated in parallel with Pck008. Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post RNAi targeting 85/88 kDa calcium-independent phospholipase A2 ( Pla2g6 ) and submitted to proteomics analysis ( Table S1 ). Pla2g6 is an enzyme that metabolizes phosphatidylcholine (PCs) into...

This data package consists of mouse MIN6 cells treated with IL-1β + IFNγ + TNFα for 0 min, 15 min, 2 hr, and 24 hr, alongside an untreated 24 hr control, and submitted to global and PTM proteomics (carbamylation and acetylation) analysis (n=3) ( Table S1 ). This was designed to characterize the...

This data package consists of data from MIN6 cells (n=3) treated with IFNγ + IL-1β + TNFα with or without DFMO or N1,N11-diethylnorspermine (DENSpm) and submitted to RNA-seq ( Table S1 ). DENSpm is an inhibitor of ornithine decarboxylase (ODC) and polyamine oxidase (PAOX), both enzymes in the...

The data package consists of RNA-seq data from human islet-derived exosomes post IFNγ + IL-1β treatment of human islets (n=5) for 24 h ( Table S1 ). Data contributors: Preethi Krishnan& Carmella Evans-Molina: Department of Diabetes Immunology, Beckman Research Institute, City of Hope, Duarte, CA...

This data package consists of data from human islets (n=8) treated with IFNγ + IL-1β for 24 h and submitted to phosphoproteomics ( Table S1 ). Data contributor: Wei-Jun Qian: Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, 99354, USA. Data repository: PXD011857...

This data package consists of data from human islets (n=5) treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq analysis ( Table S1 ). Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty, Université Libre de Bruxelles...

The data package consists of RNA-seq datasets of EndoC-βH1 cells treated in parallel with IFNα, IFNγ, IL-1β and TNFα for 24 h and submitted to RNA-seq (n=4) ( Table S1 ) Data contributors: Arturo Roca-Rivada, Xiaoyan Yi & Décio L. Eizirik: ULB Center for Diabetes Research, Medical Faculty...

This data package consists of data from MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post-RNAi targeting ADP-ribosylhydrolase ARH3 (Adprhl2), and submitted to proteomics analysis ( Table S1 ). ARH3 is a hydrolase that keeps cellular ADP-ribosylation levels in check and is regulated by...