It consists of human islets (n=10) treated with IFNγ + IL-1β for 24 h and submitted to RNA-seq analysis ( Table 1 ). Data repository: GSE169221 Publication: PMID 34957512

It consists of human islets (n=5) treated with IFNγ + IL-1β for 24 h and RNAs from islet-derived extracellular vesicles were purified and analyzed by total RNA-seq ( Table 1 ). Data repository: GSE139932 Publication: PMID 31775218

It consists of MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα and RNAi targeting Poly(ADP)ribosyl polymerase 12 ( Parp12 ) for 24 h and submitted to proteomic analyses ( Table 1 ). PARP12 is an interferon-induced protein known to target viral RNA to stress granules. It has been reported to have...

It consists of MIN6 cells (n=4) treated with IL-1β + IFNγ + TNFα for 24 h post-RNAi targeting ADP-ribosylhydrolase ARH3 (Adprhl2), and submitted to proteomics analysis ( Table 1 ). ARH3 is a hydrolase that keeps cellular ADP-ribosylation levels in check and is regulated by omega-3 FA to protect β...

It consists of human islets (n=5) treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq analysis ( Table 1 ). Data repository: GSE35296 Publication: PMID 22412385

This data package consists of data from paired human islets treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), UMI-4C18 (n=2 or 3, depending on the viewpoint), and ChIP-seq for histone H3 lysine 27 acetylation (H3K27Ac) (n=4) ( Table 1 ). Islets across the two studies...

It consists of human islets (n=10, subdivided into 2 batches) treated with IFNγ + IL-1β for 24 h and submitted to proteomics, lipidomics and metabolomics in the same samples ( Table 1 ) Data repositories: Proteomics: PXD009131 Lipidomics: MSV000086174 Metabolomics: https://osf.io/nskdc Publications...

It consists of human islets (n=6) treated with IFNγ + IL-1β for 24 h and submitted to top-down proteomics ( Table 1 ). Data repository: MSV000097810 Publication: PMID 40977091

It consists of sets of EndoC-βH1 cells treated in parallel with IFNα, IFNγ, IL-1β and TNFα for 24 h and submitted to RNA-seq (n=4) ( Table 1 ) Data repository: GSE235683 Publication: PMID 38409439

It consists of human islets (n=8) treated with IFNγ + IL-1β for 24 h and submitted to phosphoproteomics ( Table 1 ). Data repository: PXD011857 Publication: PMID 30843680

It consists of sets of β-TC-3 cells (n=3) treated with IL-1β + IFNγ + TNFα for 24 h with or without ML351 and submitted to RNA-seq ( Table 1 ). ML351 is an inhibitor of 12-lipoxygenase, an enzyme that produces 12-HETE. Therefore, this treatment was done to study whether inhibiting 12-HETE synthesis...

It consists of human islets (n=5) treated with IFNγ + IL-1β with or without difluoromethylornithine (DFMO) and submitted to RNA-seq and proteomics analysis ( Table 1 ). DFMO is an inhibitor of ornithine decarboxylase (ODC), an enzyme of the polyamine pathway. Therefore, this treatment was done to...

It consists of iPSC: HEL115.6-derived islet-like aggregates treated with IFNα for 24 h and submitted to RNA-seq (n=5) and scRNA-seq (n=5). ( Table 1 ). Data repository: RNA-seq: GSE203430 scRNA-seq: GSE203384 Publication: PMID 36103539

This data package consists of data from human islets and EndoC-βH1 cells treated with IFNα for 2, 8, or 24 h and submitted to RNA-seq (human islets: n=6 & EndoC-βH1: n=5) and ATAC-seq (n=4). In parallel, a batch of cells (n=4) had proteomics, lipidomics, and metabolomics performed in the same...

This data package consists of data from parallel experiments compared to Pck001 but performed with EndoC-βH1 cells instead of human islets. Cells were treated with IFNγ + IL-1β for 48 h and submitted to RNA-seq (n=5), ATAC-seq (n=5), DNA methylation (n=5) and H3K27Ac ChIP-seq (n=4). In addition...