The soil microbiome performs many functions that are key to ecology, agriculture, and nutrient cycling. However, because of the complexity of this ecosystem we do not know the molecular details of the interactions between microbial species that lead to these important functions. Here, we use a...
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"Moisture modulates soil reservoirs of active DNA and RNA viruses" Soil is known to harbor viruses, but the majority are uncharacterized and their responses to environmental changes are unknown. Here, we used a multi-omics approach (metagenomics, metatranscriptomics and metaproteomics) to detect...
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Emeritus Professor Forage and Extension Agronomist at Washington State University https://css.wsu.edu/profile/?nid=fransen
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Katherine joined the Sprunger Lab at the W. K. Kellogg Biological Station (part of Michigan State University) in January 2023. She came to KBS from Washington State University, where she earned her Ph.D. in soil science in 2022. Her research interests include agroecology with respect to how land...
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Two factors that are well-known to influence soil microbiomes are the depth of the soil as well as the level of moisture. Previous works have demonstrated that climate change will increase the incidence of drought in soils, but it is unknown how fluctuations in moisture availability affect soil...
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This project will improve current understanding of how viruses manipulate host environments. Use cutting edge, iterative proteomics and metabolomics tools in ex vivo primary human lung cultures that recapitulate the epithelium of the conducting airway and novel high throughput sample capture...
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By developing explainable, predictive metabolic models of individual microbes, we aim to design consortia that convert light and abundant atmospheric gases into high-value molecules through microbial division of labor.
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The research goal of this project is to build and understand model communities that show carbon storage phenotypes
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The research goal of this project is to develop a biologically informed machine learning (ML) model that integrates datasets from different studies, and leverages current biological knowledge in an automated manner, to improve predictions in biological data analysis.
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The research goal of this project is to construct and streamline an approach to identify phenotype-relevant signatures by integrating various proteomics data. Leveraging protein structures and interaction networks, we will map structural changes and post-translational modifications to identify...
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The research goal of this project is to develop computational methods to predict cell regulation phenotypes using small molecule and proteome data to understand outcomes in complex biological systems.
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The research goal of this project is to develop new theory and tools that leverage evolutionary perspectives and knowledge of the energetics of reactions to predict the most likely regulation in a given environment. These methods will accelerate exploration, modeling and understanding of cell...
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Ethan is an applied mathematician with experience in control, optimization, modeling, and machine learning. He is interested in leveraging the tools and successes of data science to push the boundaries of complexity and scale possible within scientific computing. Within modeling, his interests are...
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Jeremy Zucker is a computational scientist in the department of computational biology at Pacific Northwest National Laboratory. He is a principal investigator for a variety of sponsors, including DARPA, DOE, and internally funded LDRDs. He uses machine learning-powered causal models — abstract and...
